La teoría MWC (Monod, Wyman y Changeux): El sistema alostérico

Abstract

The aim of this paper is to present the first steps of a structuralist reconstruction of MWC (Monod, Wyman and Changeux’) allosteric theory. This theory was presented in two articles published in Journal of Molecular Biology, in the first one, “Alosteric proteins and cellular control systems” (1963), a simplified version, and in the second one, “On the nature of allosteric transitions: a plausible model”, published in the same journal in 1965, in a more complete version. In these articles, the winner of the Nobel Prize in Physiology Jacques Monod introduces for the first time a new concept that will revolutionize the biochemistry and biology of the time: allosterism.